What Is Sjogren's Syndrome? | HealthInfi

Sjogren’s (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth.Although you can develop Sjogren’s syndrome at any age, most people are older than 40 at the time of diagnosis. The condition is much more common in women. Treatment focuses on relieving symptoms.

Women are nine times more likely than men to develop Sjögren’s syndrome, achronic, incurable disorder in whichimmune system cells attack and destroy the glands that produce moisture. Sjögren’s (pronounced “show-grins”) can occur at any age, but a woman is at higher risk for developing the condition after menopause.

The Sjögren’s Syndrome Foundation estimates that four million Americans suffer from this disorder; many go undiagnosed.

The syndrome, named after Swedish ophthalmologist Henrik Sjögren, is an autoimmune disorder—a disorder in which your immune system attacks your body’s healthy tissues. Ordinarily, the immune system produces antibodies and cells that target such destructive material as viruses and bacteria. In the case of Sjögren’s and other autoimmune diseases, the immune system produces autoreactive cells and autoantibodies, which turn against the part of the body they should protect.

The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. In Sjogren’s syndrome, the mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first — resulting in decreased tears and saliva.

Types of Sjogren Syndrome: Primary and Secondary

Sjögren’s syndrome may occur alone (referred to as primary Sjögren’s syndrome), or it may be associated with other autoimmune/rheumatic diseases, such as rheumatoid arthritis, lupus, polymyositis and scleroderma. When Sjögren’s occurs with another autoimmune disease it is called secondary Sjögren’s syndrome.

Symptoms of Sjogren Syndrome

Common Symptoms

Symptoms

• Salivary glands

The two main symptoms of Sjogren’s syndrome are:

• Dry eyes. Your eyes might burn, itch or feel gritty — as if there’s sand in them.
• Dry mouth. Your mouth might feel like it’s full of cotton, making it difficult to swallow or speak.

Some people with Sjogren’s syndrome also have one or more of the following:

• Joint pain, swelling and stiffness
• Swollen salivary glands — particularly the set located behind your jaw and in front of your ears
• Skin rashes or dry skin
• Vaginal dryness
• Persistent dry cough
• Prolonged fatigue

Causes

Sjogren’s syndrome is an autoimmune disorder. Your immune system mistakenly attacks your body’s own cells and tissues.

Scientists aren’t certain why some people develop Sjogren’s syndrome. Certain genes put people at higher risk of the disorder, but it appears that a triggering mechanism — such as infection with a particular virus or strain of bacteria — is also necessary.

In Sjogren’s syndrome, your immune system first targets the glands that make tears and saliva. But it can also damage other parts of your body, such as:

• Joints
• Thyroid
• Kidneys
• Liver
• Lungs
• Skin
• Nerves

Risk factors

Sjogren’s syndrome typically occurs in people with one or more known risk factors, including:

• Age. Sjogren’s syndrome is usually diagnosed in people older than 40.
• Sex. Women are much more likely to have Sjogren’s syndrome.
• Rheumatic disease. It’s common for people who have Sjogren’s syndrome to also have a rheumatic disease — such as rheumatoid arthritis or lupus.

Complications

The most common complications of Sjogren’s syndrome involve your eyes and mouth.

• Dental cavities. Because saliva helps protect the teeth from the bacteria that cause cavities, you’re more prone to developing cavities if your mouth is dry.
• Yeast infections. People with Sjogren’s syndrome are much more likely to develop oral thrush, a yeast infection in the mouth.
• Vision problems. Dry eyes can lead to light sensitivity, blurred vision and corneal damage.

Less common complications might affect:

• Lungs, kidneys or liver. Inflammation can cause pneumonia, bronchitis or other problems in your lungs; lead to problems with kidney function; and cause hepatitis or cirrhosis in your liver.
• Lymph nodes. A small percentage of people with Sjogren’s syndrome develop cancer of the lymph nodes (lymphoma).
• Nerves. You might develop numbness, tingling and burning in your hands and feet (peripheral neuropathy).

The hallmark symptoms of Sjögren’s are dry eyes and dry mouth. The disorder may also cause skin, nose and vaginal dryness, and it can affect other organs of the body as well, including your skin, lungs, gastrointestinal tract, liver, pancreas, kidneys,thyroid, joints, muscles, blood, blood vessels, brain, spinal cord and peripheral nerves.Read More